A novel mode of action for COX‐2 inhibition: Targeting ATPase domain of HSP90 induces ubiquitin degradation of new client protein COX‐2

• Man Zhang,
• Jing Cui,
• Fukui Shen,
• Lili Ye,
• Chuanjing Cheng,
• Yang Li,
• Qiuyang Zhang,
• Lin Niu,
• Yuanyuan Hou,
• Gang Bai

Affiliations

Man Zhang

State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin People's Republic of China

Jing Cui

State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin People's Republic of China

Fukui Shen

State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin People's Republic of China

Lili Ye

State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin People's Republic of China

Chuanjing Cheng

State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin People's Republic of China

Yang Li

State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin People's Republic of China

Qiuyang Zhang

Thompson Rivers University Manna British Columbia Canada

Lin Niu

Tianjin University of Traditional Chinese Medicine Tianjin People's Republic of China

Yuanyuan Hou

State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin People's Republic of China

Gang Bai

State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin People's Republic of China