Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells

• Chiara Trigili,
• Isabel Barasoain,
• Pedro A. Sánchez-Murcia,
• Katja Bargsten,
• Mariano Redondo-Horcajo,
• Aurora Nogales,
• Nicola M. Gardner,
• Arndt Meyer,
• Guy J. Naylor,
• Elena Gómez-Rubio,
• Federico Gago,
• Michel O. Steinmetz,
• Ian Paterson,
• Andrea E. Prota,
• J. Fernando Díaz

Affiliations

Chiara Trigili

Chemical and Physical Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

Isabel Barasoain

Chemical and Physical Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

Pedro A. Sánchez-Murcia

Área de Farmacología, Departamento de Ciencias Biomédicas, Universidad de Alcalá, Unidad Asociada al IQM (CSIC), Madrid, Spain

Katja Bargsten

Department of Biology and Chemistry Laboratory of Biomolecular Research, Paul Scherrer Institut (PSI), Villigen, Switzerland

Mariano Redondo-Horcajo

Chemical and Physical Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

Aurora Nogales

Instituto de Estructura de la Materia, Consejo Superior de Investigaciones Científicas IEM-CSIC, Madrid, Spain

Nicola M. Gardner

University Chemical Laboratory, University of Cambridge, Cambridge, U.K.

Arndt Meyer

University Chemical Laboratory, University of Cambridge, Cambridge, U.K.

Guy J. Naylor

University Chemical Laboratory, University of Cambridge, Cambridge, U.K.

Elena Gómez-Rubio

Área de Farmacología, Departamento de Ciencias Biomédicas, Universidad de Alcalá, Unidad Asociada al IQM (CSIC), Madrid, Spain

Federico Gago

Área de Farmacología, Departamento de Ciencias Biomédicas, Universidad de Alcalá, Unidad Asociada al IQM (CSIC), Madrid, Spain

Michel O. Steinmetz

Department of Biology and Chemistry Laboratory of Biomolecular Research, Paul Scherrer Institut (PSI), Villigen, Switzerland

Ian Paterson

University Chemical Laboratory, University of Cambridge, Cambridge, U.K.

Andrea E. Prota

Department of Biology and Chemistry Laboratory of Biomolecular Research, Paul Scherrer Institut (PSI), Villigen, Switzerland

J. Fernando Díaz

Chemical and Physical Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain