Morphological and biochemical indices of necro-inflammatory and fibrotic changes in the liver and their relationship between viral load in patients with CVH

Abstract

The study involved 255 patients with chronic viral hepatitis. It was found that histological activity index and fibrosis stage do not depend on the genotype of HCV in patients with СHC and do not depend on HBeAg status in patients with СHВ. In HBV/HCV coinfected patients histological activity index was higher if HBV replication is dominated. Viral load in patients with СHC and СHВ significantly weakly correlates with HAI and does not correlate with fibrosis stage. In 40% of patients with CHC and 23% of patients with CHB and low viral load HAI was > 9 points, and in 26% and 41% of patients respectively fibrosis stage was > 2 points.

Keywords

• chronic viral hepatitis
• viral load
• histological activity index
• fibrosis stage