Journal of Orthopaedic Translation (Sep 2023)
Stem cell-based therapeutic strategies for rotator cuff tendinopathy
- Zetao Wang,
- Youguo Liao,
- Canlong Wang,
- Chenqi Tang,
- Cailian Fang,
- Junchao Luo,
- Hengzhi Liu,
- Xianan Mo,
- Zicheng Wang,
- Lingfang Shen,
- Junjuan Wang,
- Xiao Chen,
- Zi Yin,
- Jianyou Li,
- Weiliang Shen
Affiliations
- Zetao Wang
- Department of Orthopedics, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China; Department of Orthopedic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China
- Youguo Liao
- Department of Orthopedic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China
- Canlong Wang
- Department of Orthopedic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China
- Chenqi Tang
- Department of Orthopedic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Binjiang Institute of Zhejiang University, Hangzhou, China
- Cailian Fang
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China
- Junchao Luo
- Department of Orthopedic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China
- Hengzhi Liu
- Department of Orthopedic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China
- Xianan Mo
- Department of Orthopedic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Zicheng Wang
- Department of Orthopedics, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China
- Lingfang Shen
- Air Force Health Care Center for Special Services, Hangzhou, China
- Junjuan Wang
- Hangzhou Medical College, Hangzhou, China
- Xiao Chen
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China
- Zi Yin
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author. Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China
- Jianyou Li
- Department of Orthopedics, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China; Corresponding author. Department of Orthopedics, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang, 313000, China
- Weiliang Shen
- Department of Orthopedics, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China; Department of Orthopedic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; Orthopaedics Research Institute of Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author. Department of Orthopedics, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang, 313000, China
- Journal volume & issue
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Vol. 42
pp. 73 – 81
Abstract
Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant health and economic burden. Stem cell therapy has brought hope for tendon healing in patients with final stage rotator cuff tendinopathy. Some clinical trials have confirmed the effectiveness of stem cell therapy for rotator cuff tendinopathy, but its application has not been promoted and approved. There are still many issues that should be solved prior to using stem cell therapy in clinical applications. The optimal source and dose of stem cells for rotator cuff tendinopathy should be determined. We also proposed novel prospective approaches that can overcome cell population heterogeneity and standardize patient types for stem cell applications. The translational potential of this article: This review explores the optimal sources of stem cells for rotator cuff tendinopathy and the principles for selecting stem cell dosages. Key strategies are provided for stem cell population standardization and recipient selection.
