Nature Communications (Jun 2016)

Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor

  • Haig Aghajanian,
  • Young Kuk Cho,
  • Lauren J. Manderfield,
  • Madison R. Herling,
  • Mudit Gupta,
  • Vivienne C. Ho,
  • Li Li,
  • Karl Degenhardt,
  • Alla Aharonov,
  • Eldad Tzahor,
  • Jonathan A. Epstein

DOI
https://doi.org/10.1038/ncomms12038
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Semaphorin ligands and cognate receptors are important in patterning the vasculature. Here, Aghajanian et al.report an unexpected role for ErbB2 in endothelial cells where it partners with Nrp1 to form a novel semaphoring holoreceptor required for embryonic vascular patterning.