Journal of Extracellular Vesicles (Dec 2018)
Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017
- Aled Clayton,
- Dominik Buschmann,
- J. Brian Byrd,
- David R. F. Carter,
- Lesley Cheng,
- Carolyn Compton,
- George Daaboul,
- Andrew Devitt,
- Juan Manuel Falcon-Perez,
- Chris Gardiner,
- Dakota Gustafson,
- Paul Harrison,
- Clemens Helmbrecht,
- An Hendrix,
- Andrew Hill,
- Andrew Hoffman,
- Jennifer C. Jones,
- Raghu Kalluri,
- Ji Yoon Kang,
- Benedikt Kirchner,
- Cecilia Lässer,
- Charlotte Lawson,
- Metka Lenassi,
- Carina Levin,
- Alicia Llorente,
- Elena S. Martens-Uzunova,
- Andreas Möller,
- Luca Musante,
- Takahiro Ochiya,
- Ryan C Pink,
- Hidetoshi Tahara,
- Marca H. M. Wauben,
- Jason P. Webber,
- Joshua A. Welsh,
- Kenneth W. Witwer,
- Hang Yin,
- Rienk Nieuwland
Affiliations
- Aled Clayton
- Cardiff University
- Dominik Buschmann
- Technical University of Munich and Institute of Human Genetics, University Hospital, LMU Munich
- J. Brian Byrd
- University of Michigan, 5570C MSRB II
- David R. F. Carter
- Oxford Brookes University
- Lesley Cheng
- La Trobe Institute for Molecular Science, La Trobe University
- Carolyn Compton
- Arizona State University
- George Daaboul
- nanoView Diagnostics
- Andrew Devitt
- Aston University
- Juan Manuel Falcon-Perez
- Exosomes Laboratory & Metabolomics Platform, CIC bioGUNE, CIBEREHD, IKERBASQUE Research Foundation
- Chris Gardiner
- Haemostasis Research, University College London
- Dakota Gustafson
- University of Toronto
- Paul Harrison
- University of Birmingham
- Clemens Helmbrecht
- Particle Metrix GmbH
- An Hendrix
- Ghent University, Ghent, Belgium; and Cancer Research Institute Ghent
- Andrew Hill
- La Trobe Institute for Molecular Science, La Trobe University
- Andrew Hoffman
- Tufts University
- Jennifer C. Jones
- National Cancer Institute
- Raghu Kalluri
- Metastasis Research Center, UT MD Anderson Cancer Center
- Ji Yoon Kang
- Korea Institute of Science and Technology, Center for Bio-microsystems
- Benedikt Kirchner
- TUM School of Life Sciences Weihenstephan, Technical University of Munich
- Cecilia Lässer
- Institute of Medicine at Sahlgrenska Academy Krefting Research Centre University of Gothenburg
- Charlotte Lawson
- Royal Veterinary College Royal College Street
- Metka Lenassi
- University of Ljubljana
- Carina Levin
- Technion
- Alicia Llorente
- Oslo University Hospital
- Elena S. Martens-Uzunova
- Erasmus MC
- Andreas Möller
- Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute
- Luca Musante
- University of Virginia
- Takahiro Ochiya
- National Cancer Center Research Institute
- Ryan C Pink
- Oxford Brookes University
- Hidetoshi Tahara
- Institute and Graduate School of Biomedical & Health Sciences, Hiroshima University
- Marca H. M. Wauben
- Utrecht University
- Jason P. Webber
- Cardiff University
- Joshua A. Welsh
- National Cancer Institute
- Kenneth W. Witwer
- Johns Hopkins Institute for NanoBio Technology, Johns Hopkins University
- Hang Yin
- Tsinghua University
- Rienk Nieuwland
- Academic Medical Center, University of Amsterdam
- DOI
- https://doi.org/10.1080/20013078.2018.1473707
- Journal volume & issue
-
Vol. 7,
no. 1
Abstract
This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
Keywords
