BMJ Open (Jun 2023)
Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia
- ,
- Martin McKibbin,
- Tariq Aslam,
- Sarah Barman,
- Jenny Barrett,
- Paul Bishop,
- Roxana Carare,
- Usha Chakravarthy,
- Michelle Chan,
- Alexander Day,
- Parul Desai,
- Bal Dhillon,
- Andrew Dick,
- Cathy Egan,
- Sarah Ennis,
- Paul Foster,
- Marcus Fruttiger,
- John Gallacher,
- Jane Gibson,
- Jeremy Guggenheim,
- Chris Hammond,
- Alison Hardcastle,
- Simon Harding,
- Ruth Hogg,
- Pirro Hysi,
- Anthony Khawaja,
- Gerassimos Lascaratos,
- Andrew Lotery,
- Phil Luthert,
- Tom Macgillivray,
- Sarah Mackie,
- Bernadette Mcguinness,
- Gareth Mckay,
- Tony Moore,
- James Morgan,
- Eoin O’sullivan,
- Chris Owen,
- Praveen Patel,
- Euan Paterson,
- Axel Petzold,
- Alicja Rudnicka,
- Paul J Foster,
- Naomi Allen,
- Peng Tee Khaw,
- Praveen J Patel,
- Konstantinos Balaskas,
- Richard Oram,
- Robert Luben,
- Tasanee Braithwaite,
- Graeme Black,
- Christopher G Owen,
- Zihan Sun,
- David Garway-Heath,
- Thomas Littlejohns,
- Simon Sheard,
- Sharon Chua,
- Pearse Keane,
- Denize Atan,
- Savita Madhusudhan,
- Alexander Doney
Affiliations
- Military Hospital Ulm; Oberer Eselsberg 40; 89081 Ulm; Germany
- Martin McKibbin
- Tariq Aslam
- Sarah Barman
- Jenny Barrett
- Paul Bishop
- Roxana Carare
- Usha Chakravarthy
- Michelle Chan
- Alexander Day
- Parul Desai
- Bal Dhillon
- Andrew Dick
- Cathy Egan
- Sarah Ennis
- Paul Foster
- Marcus Fruttiger
- John Gallacher
- Jane Gibson
- Jeremy Guggenheim
- Chris Hammond
- Alison Hardcastle
- Simon Harding
- Ruth Hogg
- Pirro Hysi
- Anthony Khawaja
- 3 NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK
- Gerassimos Lascaratos
- Andrew Lotery
- 4 Faculty of Medicine, University of Southampton, Southampton, UK
- Phil Luthert
- Tom Macgillivray
- 5 Clinical Research Imaging Centre, Queens Medical Research Institution, Edinburgh, UK
- Sarah Mackie
- Bernadette Mcguinness
- Gareth Mckay
- Tony Moore
- James Morgan
- Eoin O’sullivan
- Chris Owen
- Praveen Patel
- Euan Paterson
- Axel Petzold
- 9 Departments of Neurology, Ophthalmology and Expertise Center for Neuro-ophthalmology, Amsterdam UMC, Amsterdam, The Netherlands
- Alicja Rudnicka
- 6 Population Health Research Institute, St Georges Medical School, University of London, London, UK
- Paul J Foster
- 1 Moorfields Eye Hospital NHS Foundation Trust, NIHR Moorfields Biomedical Research Centre, London, UK
- Naomi Allen
- 11 UK Biobank, Stockport, UK
- Peng Tee Khaw
- Praveen J Patel
- 7 NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK
- Konstantinos Balaskas
- UCL Institute of Ophthalmology, University College London, London, UK
- Richard Oram
- Robert Luben
- Tasanee Braithwaite
- Graeme Black
- Christopher G Owen
- 6 Population Health Research Institute, St Georges Medical School, University of London, London, UK
- Zihan Sun
- 10 Institute of Ophthalmology, University College London, London, UK
- David Garway-Heath
- Thomas Littlejohns
- Simon Sheard
- 11 UK Biobank, Stockport, UK
- Sharon Chua
- Pearse Keane
- Denize Atan
- Bristol Eye Hospital, University Hospitals Bristol & Weston NHS Foundation Trust, Bristol, UK
- Savita Madhusudhan
- Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
- Alexander Doney
- DOI
- https://doi.org/10.1136/bmjopen-2022-069258
- Journal volume & issue
-
Vol. 13,
no. 6
Abstract
Purpose The retina provides biomarkers of neuronal and vascular health that offer promising insights into cognitive ageing, mild cognitive impairment and dementia. This article described the rationale and methodology of eye and vision assessments with the aim of supporting the study of dementia in the UK Biobank Repeat Imaging study.Participants UK Biobank is a large-scale, multicentre, prospective cohort containing in-depth genetic, lifestyle, environmental and health information from half a million participants aged 40–69 enrolled in 2006–2010 across the UK. A subset (up to 60 000 participants) of the cohort will be invited to the UK Biobank Repeat Imaging Study to collect repeated brain, cardiac and abdominal MRI scans, whole-body dual-energy X-ray absorptiometry, carotid ultrasound, as well as retinal optical coherence tomography (OCT) and colour fundus photographs.Findings to date UK Biobank has helped make significant advances in understanding risk factors for many common diseases, including for dementia and cognitive decline. Ophthalmic genetic and epidemiology studies have also benefited from the unparalleled combination of very large numbers of participants, deep phenotyping and longitudinal follow-up of the cohort, with comprehensive health data linkage to disease outcomes. In addition, we have used UK Biobank data to describe the relationship between retinal structures, cognitive function and brain MRI-derived phenotypes.Future plans The collection of eye-related data (eg, OCT), as part of the UK Biobank Repeat Imaging study, will take place in 2022–2028. The depth and breadth and longitudinal nature of this dataset, coupled with its open-access policy, will create a major new resource for dementia diagnostic discovery and to better understand its association with comorbid diseases. In addition, the broad and diverse data available in this study will support research into ophthalmic diseases and various other health outcomes beyond dementia.
