Açai (Euterpe oleracea Mart.) supplementation promotes histological and ultrastructural changes in rats' alveolar bone
João Daniel Mendonça de Moura,
Patricia de Almeida Rodrigues,
Vinicius Ruan Neves Dos Santos,
Leonardo Oliveira Bittencourt,
José Mario Matos-Sousa,
Beatriz Rodrgiues Risuenho Peinado,
José Messias Perdigão,
Herve Rogez,
Fabrício Mezzomo Collares,
Rafael Rodrigues Lima
Affiliations
João Daniel Mendonça de Moura
Department of Dentistry, School of Dentistry, Federal University of Pará, Belém, Pará, Brazil
Patricia de Almeida Rodrigues
Department of Dentistry, School of Dentistry, Federal University of Pará, Belém, Pará, Brazil
Vinicius Ruan Neves Dos Santos
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil
Leonardo Oliveira Bittencourt
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil
José Mario Matos-Sousa
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil
Beatriz Rodrgiues Risuenho Peinado
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil
José Messias Perdigão
Center for Valorization of Amazonian Bioactive Compounds, College of Biotechnology, Federal University of Pará, Belém, Pará, Brazil
Herve Rogez
Center for Valorization of Amazonian Bioactive Compounds, College of Biotechnology, Federal University of Pará, Belém, Pará, Brazil
Fabrício Mezzomo Collares
Dental Materials Laboratory, Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil
Rafael Rodrigues Lima
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil; Corresponding author. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Street Augusto Corrêa Street, n. 1, Guamá, Belém, Pará, 66075-110, Brazil.
The açai juice contains high concentrations of phenolic compounds, including cyanidin-3-glucoside and others flavonoids. The aim of this study was to evaluate the impact of açai supplementation on healthy mandibular alveolar bone in male albino rats of the Wistar strain. 24 rats were divided into 3 groups, in which one group received a daily dose of saline solution and the other two groups were treated with daily doses of clarified açai juice for 14 or 28 days. After the experiment, hemimandibles were collected and analyzed using Scanning Electron Microscopy (SEM), histological assessments, and micro-CT. Results showed changes in the integrity of the alveolar bone as seen in SEM, increased osteocyte density and higher collagen matrix area in the açai group compared to the control group as seen in histological analysis, and increased bone volume, trabecular thickness and number, and cortical bone as seen in micro-CT analysis. The space between bone trabeculae showed no difference among the groups. These results suggest that açai supplementation may have a structural change effect on alveolar bone, but further research is needed to confirm these findings in humans and to determine the exact mechanisms behind these effects.
