Marine Drugs
(Sep 2022)
Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral <i>Sarcophyton elegans</i>
Cili Wang,
Jiarui Zhang,
Xing Shi,
Kai Li,
Fengling Li,
Xuli Tang,
Guoqiang Li,
Pinglin Li
Affiliations
Cili Wang
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Jiarui Zhang
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Xing Shi
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Kai Li
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Fengling Li
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China
Xuli Tang
College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China
Guoqiang Li
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Pinglin Li
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
DOI
https://doi.org/10.3390/md20090574
Journal volume & issue
Vol. 20,
no. 9
Abstract
Read online
Five new cembranes, named sarcoeleganolides C–G (1–5), along with three known analogs (6–8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 μM.
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