Egyptian Journal of Medical Human Genetics (Nov 2021)

TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

  • Estela Morales Peralta,
  • Yaíma Zúñiga Rosales,
  • Teresa Collazo Mesa,
  • Elvia Nelmi Santos González,
  • Yadira Hernández Pérez,
  • María de los Ángeles González Torres,
  • Hilda Roblejo Balbuena,
  • Beatriz Marcheco Teruel

DOI
https://doi.org/10.1186/s43042-021-00206-4
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 4

Abstract

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Abstract Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.

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