Recent progress in biomaterials for heart valve replacement: Structure, function, and biomimetic design
Ziyu Shao,
Tingting Tao,
Hongfei Xu,
Cen Chen,
In‐Seop Lee,
Sungmin Chung,
Zhihui Dong,
Weidong Li,
Liang Ma,
Hao Bai,
Qianming Chen
Affiliations
Ziyu Shao
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University Hangzhou 310006 China
Tingting Tao
Department of Cardiovascular Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province China
Hongfei Xu
Department of Cardiovascular Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province China
Cen Chen
College of Life Sciences and Medicine Zhejiang Sci‐Tech University Hangzhou China
In‐Seop Lee
College of Life Sciences and Medicine Zhejiang Sci‐Tech University Hangzhou China
Sungmin Chung
Biomaterials R&D Center GENOSS Co., Ltd. Suwon‐si Republic of Korea
Zhihui Dong
State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering Zhejiang University Hangzhou China
Weidong Li
Department of Cardiovascular Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province China
Liang Ma
Department of Cardiovascular Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province China
Hao Bai
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University Hangzhou 310006 China
Qianming Chen
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University Hangzhou 310006 China
Abstract Heart diseases caused by structure and function degradation is troubling millions of people all over the world. With the extension of human lifespan, the demand for heart valve replacement is rapidly increasing. However, the currently used prostheses of heart valve in clinic such as mechanical and tissue valves all have serious limitations over long‐term stability after implanting. Therefore, novel artificial heart valves with outstanding durability and low degradation risk are still in great demands, despite of numerous studies in the literature. The sophisticated, multiscale structure of native heart valve is believed to be the key to its mechanical and biological durability during long‐term cyclic motion. In this review, we discussed the complex structure of the native heart valve as well as their contributions to the valve's cyclic work. In addition, representative and state of the art studies of biomimetic heart valves inspired by the natural valve are also introduced. Based on these, the structural and functional design of future novel biomimetic heart valves are proposed.
