Nature Communications (Aug 2019)
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export
- Saskia Heybrock,
- Kristiina Kanerva,
- Ying Meng,
- Chris Ing,
- Anna Liang,
- Zi-Jian Xiong,
- Xialian Weng,
- Young Ah Kim,
- Richard Collins,
- William Trimble,
- Régis Pomès,
- Gilbert G. Privé,
- Wim Annaert,
- Michael Schwake,
- Joerg Heeren,
- Renate Lüllmann-Rauch,
- Sergio Grinstein,
- Elina Ikonen,
- Paul Saftig,
- Dante Neculai
Affiliations
- Saskia Heybrock
- Biochemisches Institut, Christian-Albrechts-Universität Kiel
- Kristiina Kanerva
- Faculty of Medicine, Anatomy and Stem Cells and Metabolism Research Program, University of Helsinki
- Ying Meng
- Department of Cell Biology, and Department of Pathology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Chris Ing
- Program in Molecular Medicine, Research Institute, The Hospital for Sick Children
- Anna Liang
- Program in Molecular Medicine, Research Institute, The Hospital for Sick Children
- Zi-Jian Xiong
- Department of Biochemistry, University of Toronto
- Xialian Weng
- Department of Cell Biology, and Department of Pathology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Young Ah Kim
- Department of Chemistry and Biochemistry, Queens College, City University of New York
- Richard Collins
- Cell Biology Program, Hospital for Sick Children
- William Trimble
- Department of Biochemistry, University of Toronto
- Régis Pomès
- Program in Molecular Medicine, Research Institute, The Hospital for Sick Children
- Gilbert G. Privé
- Department of Biochemistry, University of Toronto
- Wim Annaert
- Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research
- Michael Schwake
- Faculty of Chemistry, Biochemistry III, University of Bielefeld
- Joerg Heeren
- Institut für Biochemie und Molekulare Zellbiologie, Zentrum für Experimentelle Medizin, Universitätsklinikum Hamburg-Eppendorf
- Renate Lüllmann-Rauch
- Institut für Anatomie, Christian-Albrechts-Universität Kiel
- Sergio Grinstein
- Department of Biochemistry, University of Toronto
- Elina Ikonen
- Faculty of Medicine, Anatomy and Stem Cells and Metabolism Research Program, University of Helsinki
- Paul Saftig
- Biochemisches Institut, Christian-Albrechts-Universität Kiel
- Dante Neculai
- Department of Cell Biology, and Department of Pathology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-11425-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport.
