Research progress of different cells derived exosomes in COPD

Abstract

Exosomes are lipid bilayer vesicles secreted by almost all types of cells, which consist of various proteins, DNA, mRNA, miRNA and LncRNA. They are an important medium for communication between cells and participate in various physiological and pathological processes. In chronic obstructive pulmonary disease (COPD), bronchial epithelial cells, macrophages, neutrophils and other cells can participate in COPD airway remodeling and emphysema by secreting exosomes. Moreover, mesenchymal stem cells and adipose stem cell-derived exosomes play an important role in the treatment of COPD.

Keywords

• exosomes|copd|bronchial epithelial cell|macrophages|neutrophil