Nature Communications (Nov 2016)
An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes
- Yun Sung Cho,
- Hyunho Kim,
- Hak-Min Kim,
- Sungwoong Jho,
- JeHoon Jun,
- Yong Joo Lee,
- Kyun Shik Chae,
- Chang Geun Kim,
- Sangsoo Kim,
- Anders Eriksson,
- Jeremy S. Edwards,
- Semin Lee,
- Byung Chul Kim,
- Andrea Manica,
- Tae-Kwang Oh,
- George M. Church,
- Jong Bhak
Affiliations
- Yun Sung Cho
- The Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)
- Hyunho Kim
- Geromics Inc., Ulsan National Institute of Science and Technology (UNIST)
- Hak-Min Kim
- The Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)
- Sungwoong Jho
- Personal Genomics Institute, Genome Research Foundation
- JeHoon Jun
- Personal Genomics Institute, Genome Research Foundation
- Yong Joo Lee
- Geromics Inc., Ulsan National Institute of Science and Technology (UNIST)
- Kyun Shik Chae
- National Standard Reference Center, Korea Research Institute of Standards and Science
- Chang Geun Kim
- National Standard Reference Center, Korea Research Institute of Standards and Science
- Sangsoo Kim
- School of Systems Biomedical Science, Soongsil University
- Anders Eriksson
- Department of Zoology, University of Cambridge
- Jeremy S. Edwards
- Chemistry and Chemical Biology, UNM Comprehensive Cancer Center, University of New Mexico
- Semin Lee
- The Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)
- Byung Chul Kim
- The Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)
- Andrea Manica
- Department of Zoology, University of Cambridge
- Tae-Kwang Oh
- Infection and Immunity Research Center, Korea Research Institute of Bioscience and Biotechnology
- George M. Church
- Department of Genetics, New Research Building (NRB), Harvard Medical School
- Jong Bhak
- The Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)
- DOI
- https://doi.org/10.1038/ncomms13637
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The utility of a universal reference sequence for human genome comparisons is dependent on the ethnic origins of the individuals being sequenced. Here the authors report a Korean reference genome and consensus variome, and show that an ethnically-relevant reference can improve variant detection.
