Association of Monocyte to High-Density Lipoprotein Cholesterol Ratio with Hyperreflective Foci in Patients with Diabetic Macular Edema

Abstract

INTRODUCTION: We aimed to investigate the monocyte/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) in diabetic macular edema (DME) patients with hyperreflective foci (HF) on optical coherence tomography (OCT) and compare them with the results of patients without HF. METHODS: The data were obtained by retrospectively reviewing the data of patients followed up with a diagnosis of diabetes mellitus in the internal medicine clinic and with a diagnosis of DME in our clinic. DME patients who have blood monocyte and HDL-C levels before the treatment of DME in the laboratory archive were included in the study. DME and HF were detected by OCT. The patients with DME were divided into two groups according to the presence of HF observed on OCT. Thirty-five DME patients with HF were included in the study group. Thirty-five DME patients without HF were determined as the control group. RESULTS: The mean MHR was significantly higher in DME patients with HF (p=0.002). The optimal cutoff value of MHR for HF was 9.72. The area under the receiver operating characteristics curve was 0.681. DISCUSSION AND CONCLUSION: The MHR described as a potential biomarker of inflammation was significantly higher in DME patients with HF, suggesting that elevated MHR might be associated with severity of inflammation in DME patients.

Keywords

• biomarker
• diabetic macular edema
• hyperreflective foci
• inflammation.