Hematology, Transfusion and Cell Therapy (Apr 2024)

COMPARISON OF 68GA-PSMA AND 18F-FDG-PET/CT IN THE ASSESSMENT OF DESMOID TUMORS

  • Tobias Luis dos Reis,
  • Kaique Moraes do Amaral,
  • Najua Abou Arab,
  • Maria Emilia Seren Takahashi,
  • José Barreto Campello Carvalheira,
  • Barbara Juarez Amorim,
  • Elba Cristina Sá de Camargo Etchebehere,
  • Mariana da Cunha Lopes de Lima,
  • Allan de Oliveira Santos,
  • Ludmila Santiago Almeida,
  • Eliana Cristina Martins Miranda,
  • Carmen Silvia Passos Lima,
  • Celso Dario Ramos,
  • Sérgio Querino Brunetto,
  • Simone Kuba,
  • NAtália Tobar,
  • Carmino Antonio Souza,
  • Mariana Cortês Caleffi,
  • Mariana Fernandes França Mitre Amorim

Journal volume & issue
Vol. 46
pp. S19 – S20

Abstract

Read online

Introduction/Justification: Recently, the tracer Prostate Specific Membrane Antigen (PSMA), which can be labeled with the radioisotopes 68Ga or 18F, has been commercially introduced. Theoretically, as the name suggests, it is a substance specific to the membrane of prostate cells and prostate cancer. However, several studies have shown that it is also a marker of neoangiogenesis, leading to its uptake in various other neoplasms and benign diseases. Objectives: This study aims to evaluate the utility of radiolabeled PSMA in detecting desmoid tumors, comparing it to 18F-luorodeoxyglucose (FDG). Materials and Methods: Three participants with a confirmed diagnosis of desmoid tumor underwent PET/CT examinations with 18F-PSMA and 18F-FDG, with a maximum interval of 3 days between examinations. Images were visually compared lesion by lesion and the maximum standardized uptake value (SUV) was calculated for each lesion and each radiopharmaceutical. Results: All lesions presented uptake of both 68Ga-PSMA and 18F-FDG. In the first patient, 3 lesions were identified: a mass adjacent to the pancreas measuring 5.4 cm (FDG: SUV = 2.0) (PSMA: SUV = 8.2), a mass in the right iliac fossa measuring 7.7 cm (FDG: SUV = 3.8) (PSMA: SUV = 5.7), and another involving the duodenojejunal transition measuring 4.1 cm (FDG: SUV = 1.9) (PSMA: SUV = 3.7). In the second patient, a mass was identified adjacent to the head and uncinate process of the pancreas measuring 9.2 cm (FDG: SUV = 9.8) (PSMA: SUV = 6.1). In the third patient, an irregular retroperitoneal mass was identified at the level of the aortic bifurcation (FDG: SUV = 2.3) (PSMA: SUV = 2.4). Conclusion: Desmoid tumors can demonstrate uptake of both 68Ga-PSMA and 18F-FDG. The intensity of tracer uptake in the lesions is variable, with some showing greater uptake of FDG, others of PSMA, suggesting a potential complementary role for these radiotracers in desmoid tumors.

Keywords