The tumor therapy landscape of synthetic lethality

Biyu Zhang; Chen Tang; Yanli Yao; Xiaohan Chen; Chi Zhou; Zhiting Wei; Feiyang Xing; Lan Chen; Xiang Cai; Zhiyuan Zhang; Shuyang Sun; Qi Liu

doi:10.1038/s41467-021-21544-2

Nature Communications (Feb 2021)

The tumor therapy landscape of synthetic lethality

Biyu Zhang,
Chen Tang,
Yanli Yao,
Xiaohan Chen,
Chi Zhou,
Zhiting Wei,
Feiyang Xing,
Lan Chen,
Xiang Cai,
Zhiyuan Zhang,
Shuyang Sun,
Qi Liu

Affiliations

Biyu Zhang: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University
Chen Tang: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University
Yanli Yao: Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
Xiaohan Chen: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University
Chi Zhou: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University
Zhiting Wei: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University
Feiyang Xing: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University
Lan Chen: Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
Xiang Cai: Alibaba Cloud
Zhiyuan Zhang: Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
Shuyang Sun: Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
Qi Liu: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University

DOI: https://doi.org/10.1038/s41467-021-21544-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Various methods have been proposed to identify synthetic lethality interactions, but selective treatment opportunities for various tumors have not yet been explored. Here, the authors develop the Synthetic Lethality Knowledge Graph webserver (SLKG, http://www.slkg.net) to explore the comprehensive tumor therapy landscape and uncover cancer-specific susceptibilities based on the principle of synthetic lethality.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal