Pro-oxidative status of pregnant women suffering from thrombophilia after the first trimester of pregnancy

Abstract

Introduction: Thrombophilia is defined as a hemostatic disorder which results in thrombosis. That disorder can be permanent or transient. Also, thrombophilia can be of inherited or acquired nature. Pregnancy is a state of increased oxidative stress, due to high metabolic demands and needs for oxygen. Objective: Our main aim was to determine the levels of the oxidative stress markers in healthy pregnant women and in women that suffer from thrombophilia and determining the correlation between thrombophilia in the first trimester of pregnancy and oxidative stress. Materials and methods: This was a longitudinal study which consisted of 70 study participants, divided into two equal groups: healthy pregnant women (control group) and pregnant women that suffer from thombophilia (experimental group). Blood samples were taken from both groups in the first trimester of pregnancy (11.-14. gestational week), and were used to measure oxidative stress markers (O2-, H2O2, TBARS and NO). Results: These results show that there is a statistically significant (**p<0.01) elevation of oxidative stress markers (O2-, H2O2, NO) in the experimental group, except for TBARS, which levels were significantly lower (**p<0.01). Conclusion: The results of this study show that there is an evident increase in all of the measured pro-oxidative parameters, except for TBARS. Nevertheless, because of these high levels of H2O2, O2- i NO, we can expect their elevation during the second and third trimester, which will probably cause the rise of TBARS as well. The findings of this study point out the presence of oxidative stress in pregnant women with thrombophilia, which present an additional risk factor.

Keywords

• oxidative stress
• thrombophilia
• pregnancy
• first trimester
• free radicals