Acute liver failure in a pediatric patient with congenital dyserythropoietic anemia type I treated with deferasirox

Abstract

Congenital dyserythropoietic anemias (CDA) represent a heterogeneous group of disorders characterized by morphological abnormalities of erythroid precursor cells and various degrees of hemolysis. Iron overload is a result of continuous hemolysis and recurrent transfusions. It is treated with iron chelators, including deferasirox. We present here a case of acute liver failure in a 12 years old girl with CDA type I treated with deferasirox and discuss the approach to treatment.

Keywords

• Congenital dyserythropoietic anemia
• deferasirox
• acute liver failure
• N-acetylcysteine