Molecules (Apr 2011)

Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway

  • Xuming Deng,
  • Xuelin Wang,
  • Guoren Huang,
  • Wenhui Qian,
  • Shuang Guan,
  • Wei Wang,
  • Jing Lu

DOI
https://doi.org/10.3390/molecules16043371
Journal volume & issue
Vol. 16, no. 4
pp. 3371 – 3379

Abstract

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Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H2O2)-induced HL-7702 cell damage, inhibit H2O2-induced cytosolic free Ca2+ ([Ca2+]i) elevation, scavenge reactive oxygen species (ROS) and increase 3’-5’-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn’t influence 3’-5’-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca2+]i, ROS occur via a cAMP-dependent pathway.

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