Nature Communications (Nov 2021)
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
- Siobhan Rice,
- Thomas Jackson,
- Nicholas T. Crump,
- Nicholas Fordham,
- Natalina Elliott,
- Sorcha O’Byrne,
- Maria del Mar Lara Fanego,
- Dilys Addy,
- Trisevgeni Crabb,
- Carryl Dryden,
- Sarah Inglott,
- Dariusz Ladon,
- Gary Wright,
- Jack Bartram,
- Philip Ancliff,
- Adam J. Mead,
- Christina Halsey,
- Irene Roberts,
- Thomas A. Milne,
- Anindita Roy
Affiliations
- Siobhan Rice
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford
- Thomas Jackson
- Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford
- Nicholas T. Crump
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford
- Nicholas Fordham
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford
- Natalina Elliott
- Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford
- Sorcha O’Byrne
- Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford
- Maria del Mar Lara Fanego
- Department of Haematology, Great Ormond Street Hospital for Children
- Dilys Addy
- Department of Haematology, Great Ormond Street Hospital for Children
- Trisevgeni Crabb
- Department of Haematology, Great Ormond Street Hospital for Children
- Carryl Dryden
- Department of Haematology, Great Ormond Street Hospital for Children
- Sarah Inglott
- Department of Haematology, Great Ormond Street Hospital for Children
- Dariusz Ladon
- Department of Haematology, Great Ormond Street Hospital for Children
- Gary Wright
- Department of Haematology, Great Ormond Street Hospital for Children
- Jack Bartram
- Department of Haematology, Great Ormond Street Hospital for Children
- Philip Ancliff
- Department of Haematology, Great Ormond Street Hospital for Children
- Adam J. Mead
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford
- Christina Halsey
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Irene Roberts
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford
- Thomas A. Milne
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford
- Anindita Roy
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-021-27270-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates the disease and reveals that fetal-specific genes are potential infant-ALL drivers.
