Nature Communications (Jan 2018)
Identification of genetic elements in metabolism by high-throughput mouse phenotyping
- Jan Rozman,
- Birgit Rathkolb,
- Manuela A. Oestereicher,
- Christine Schütt,
- Aakash Chavan Ravindranath,
- Stefanie Leuchtenberger,
- Sapna Sharma,
- Martin Kistler,
- Monja Willershäuser,
- Robert Brommage,
- Terrence F. Meehan,
- Jeremy Mason,
- Hamed Haselimashhadi,
- IMPC Consortium,
- Tertius Hough,
- Ann-Marie Mallon,
- Sara Wells,
- Luis Santos,
- Christopher J. Lelliott,
- Jacqueline K. White,
- Tania Sorg,
- Marie-France Champy,
- Lynette R. Bower,
- Corey L. Reynolds,
- Ann M. Flenniken,
- Stephen A. Murray,
- Lauryl M. J. Nutter,
- Karen L. Svenson,
- David West,
- Glauco P. Tocchini-Valentini,
- Arthur L. Beaudet,
- Fatima Bosch,
- Robert B. Braun,
- Michael S. Dobbie,
- Xiang Gao,
- Yann Herault,
- Ala Moshiri,
- Bret A. Moore,
- K. C. Kent Lloyd,
- Colin McKerlie,
- Hiroshi Masuya,
- Nobuhiko Tanaka,
- Paul Flicek,
- Helen E. Parkinson,
- Radislav Sedlacek,
- Je Kyung Seong,
- Chi-Kuang Leo Wang,
- Mark Moore,
- Steve D. Brown,
- Matthias H. Tschöp,
- Wolfgang Wurst,
- Martin Klingenspor,
- Eckhard Wolf,
- Johannes Beckers,
- Fausto Machicao,
- Andreas Peter,
- Harald Staiger,
- Hans-Ulrich Häring,
- Harald Grallert,
- Monica Campillos,
- Holger Maier,
- Helmut Fuchs,
- Valerie Gailus-Durner,
- Thomas Werner,
- Martin Hrabe de Angelis
Affiliations
- Jan Rozman
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Birgit Rathkolb
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Manuela A. Oestereicher
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Christine Schütt
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Aakash Chavan Ravindranath
- German Center for Diabetes Research (DZD)
- Stefanie Leuchtenberger
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Sapna Sharma
- German Center for Diabetes Research (DZD)
- Martin Kistler
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Monja Willershäuser
- Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan
- Robert Brommage
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Terrence F. Meehan
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton
- Jeremy Mason
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton
- Hamed Haselimashhadi
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton
- IMPC Consortium
- Tertius Hough
- Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre)
- Ann-Marie Mallon
- Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre)
- Sara Wells
- Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre)
- Luis Santos
- Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre)
- Christopher J. Lelliott
- The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton
- Jacqueline K. White
- The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton
- Tania Sorg
- CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)
- Marie-France Champy
- CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)
- Lynette R. Bower
- Mouse Biology Program, University of California
- Corey L. Reynolds
- Department of Molecular and Human Genetics, Baylor College of Medicine, 7702 Main St, Houston Medical Center
- Ann M. Flenniken
- The Centre for Phenogenomics
- Stephen A. Murray
- The Jackson Laboratory
- Lauryl M. J. Nutter
- The Centre for Phenogenomics
- Karen L. Svenson
- The Jackson Laboratory
- David West
- Children’s Hospital Oakland Research Institute
- Glauco P. Tocchini-Valentini
- Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Adriano Buzzati-Traverso Campus
- Arthur L. Beaudet
- The Centre for Phenogenomics
- Fatima Bosch
- Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona
- Robert B. Braun
- The Jackson Laboratory
- Michael S. Dobbie
- Australian Phenomics Network, John Curtin School of Medical Research, Australian National University
- Xiang Gao
- SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University
- Yann Herault
- CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)
- Ala Moshiri
- Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis
- Bret A. Moore
- William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, U.C. Davis
- K. C. Kent Lloyd
- Mouse Biology Program, University of California
- Colin McKerlie
- The Centre for Phenogenomics
- Hiroshi Masuya
- RIKEN BioResource Center
- Nobuhiko Tanaka
- RIKEN BioResource Center
- Paul Flicek
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton
- Helen E. Parkinson
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton
- Radislav Sedlacek
- Czech Centre for Phenogenomics, Institute of Molecular Genetics
- Je Kyung Seong
- Korea Mouse Phenotyping Consortium (KMPC) and BK21 Program for Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University
- Chi-Kuang Leo Wang
- National Laboratory Animal Center, National Applied Research Laboratories (NARLabs)
- Mark Moore
- IMPC
- Steve D. Brown
- Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre)
- Matthias H. Tschöp
- German Center for Diabetes Research (DZD)
- Wolfgang Wurst
- Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH
- Martin Klingenspor
- Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan
- Eckhard Wolf
- German Center for Diabetes Research (DZD)
- Johannes Beckers
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Fausto Machicao
- Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tübingen
- Andreas Peter
- German Center for Diabetes Research (DZD)
- Harald Staiger
- German Center for Diabetes Research (DZD)
- Hans-Ulrich Häring
- German Center for Diabetes Research (DZD)
- Harald Grallert
- German Center for Diabetes Research (DZD)
- Monica Campillos
- German Center for Diabetes Research (DZD)
- Holger Maier
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Helmut Fuchs
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Valerie Gailus-Durner
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Thomas Werner
- Internal Medicine Nephrology and Center for Computational Medicine & Bioinformatics, University of Michigan
- Martin Hrabe de Angelis
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- DOI
- https://doi.org/10.1038/s41467-017-01995-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.
