Frontiers in Oncology (Aug 2024)

Insights into uveitis from Brentuximab vedotin in refractory Hodgkin’s lymphoma: a case report and brief review

  • Mengyuan Liu,
  • Kexing Ren,
  • Ping Ai,
  • Liqun Zou

DOI
https://doi.org/10.3389/fonc.2024.1419145
Journal volume & issue
Vol. 14

Abstract

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This case report describes a 16-year-old patient with refractory Hodgkin’s lymphoma who developed bilateral anterior and intermediate uveitis as an adverse reaction to Brentuximab vedotin (BV). This is a rare case of an ocular adverse reaction potentially related to BV, with symptoms like blurred vision, decreased visual acuity, photophobia, and redness. Potential mechanisms include BV targeting CD30+ T cells in the uveal tissue or an immune response triggered by the microtubule-disrupting agent MMAE within BV. This highlights the need for vigilant monitoring of ocular adverse events in BV-treated patients and further research into their mechanisms and management.

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