Vascular Health and Risk Management (Oct 2019)

Association Between Adherence To The French Dietary Guidelines And Lower Resting Heart Rate, Longer Diastole Duration, And Lower Myocardial Oxygen Consumption. The NUTRIVASC Study

  • Fysekidis M,
  • Kesse-Guyot E,
  • Valensi P,
  • Arnault N,
  • Galan P,
  • Hercberg S,
  • Cosson E

Journal volume & issue
Vol. Volume 15
pp. 463 – 475

Abstract

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Marinos Fysekidis,1,2 Emmanuelle Kesse-Guyot,2 Paul Valensi,1 Nathalie Arnault,2 Pilar Galan,2 Serge Hercberg,2 Emmanuel Cosson1,2 1AP-HP, Department of Endocrinology-Diabetology-Nutrition, CRNH-Idf, CINFO, Paris 13 University, Hôpital Jean Verdier, Bondy, France; 2Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Université Paris 13, Inserm (U1153), Inra (U1125), Centre d’Epidémiologie et Statistiques Paris Cité, Cnam, COMUE Sorbonne-Paris-Cité, Bobigny F-93017, FranceCorrespondence: Emmanuel CossonDepartment of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, avenue du 14 Juillet, Bondy cedex 93143, FranceTel +33 148026580Fax +33 148026579Email [email protected]: To investigate whether chronic adherence to the French Nutrition and Health Program (PNNS) guidelines was associated with better cardiovascular health.Methods: A study nested within the SU.VI.MAX2 cohort was conducted on participants without cardiovascular risk factors. Long-term adherence to the PNNS guidelines was estimated using validated dietary scores from 2007 and 2012. Individuals who did (PNNS+) and did not (PNNS−) continuously adhere to the PNNS guidelines were included. Applanation tonometry, impedance cardiography, laser doppler flowmetry, heart rate, heart rate variability, endothelial function was used for the assessment of cardiovascular health.Results: A total of 49 subjects (mean age 65.4 ± 5.6 years, 75.5% women) had been included. Those in the PNNS+ group (n=26) were older, had a higher BMI and fat mass than those in the PNNS− group, both groups had similar metabolic parameters. After adjusting for sex, age, and BMI, PNNS+ subjects were found to have a lower heart rate (60.2 ± 8.0 vs 64.3 ± 8.4 beats/min, p=0.042), a lower heart rate × systolic blood pressure product (7166 ± 1323 vs 7788 ± 1680 beats× mmHg/min, p = 0.009), a longer diastole duration (66.7 ± 3.1% vs 64.6 ± 4.1% of the cardiac cycle duration, p=0.049), and a shorter tension–time index (2145 ± 489 vs 2307 ± 428 ms * mmHg, p=0.018) compared to the PNNS− group.Conclusion: Long-term adherence to the PNNS guidelines had a favorable impact on heart rate, diastole duration, and myocardial oxygen consumption.Clinical Trial Registration number: NCT01579409.Keywords: French Health and Nutrition Program, PNNS, heart rate, arterial stiffness, cutaneous blood flow, endothelial function, heart rate variability

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