Frontiers in Human Neuroscience (Oct 2020)
β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood–Brain Barrier Opening in Alzheimer’s Disease
- Pierre-François D’Haese,
- Pierre-François D’Haese,
- Pierre-François D’Haese,
- Pierre-François D’Haese,
- Manish Ranjan,
- Manish Ranjan,
- Alexander Song,
- Marc W. Haut,
- Marc W. Haut,
- Jeffrey Carpenter,
- Jeffrey Carpenter,
- Gerard Dieb,
- Gerard Dieb,
- Umer Najib,
- Umer Najib,
- Peng Wang,
- Peng Wang,
- Rashi I. Mehta,
- Rashi I. Mehta,
- J. Levi Chazen,
- Sally Hodder,
- Daniel Claassen,
- Michael Kaplitt,
- Ali R. Rezai,
- Ali R. Rezai
Affiliations
- Pierre-François D’Haese
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Pierre-François D’Haese
- Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States
- Pierre-François D’Haese
- Department of Neurological Surgery, Vanderbilt University, Nashville, TN, United States
- Pierre-François D’Haese
- Department of Neuroradiology, West Virginia University, Nashville, TN, United States
- Manish Ranjan
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Manish Ranjan
- Department of Neurosurgery, West Virginia University, Nashville, TN, United States
- Alexander Song
- Department of Neurology, Vanderbilt University, Nashville, TN, United States
- Marc W. Haut
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Marc W. Haut
- Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, United States
- Jeffrey Carpenter
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Jeffrey Carpenter
- Department of Neuroradiology, West Virginia University, Nashville, TN, United States
- Gerard Dieb
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Gerard Dieb
- Department of Neuroradiology, West Virginia University, Nashville, TN, United States
- Umer Najib
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Umer Najib
- Department of Neurology, West Virginia University, Morgantown, WV, United States
- Peng Wang
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Peng Wang
- Department of Neuroradiology, West Virginia University, Nashville, TN, United States
- Rashi I. Mehta
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Rashi I. Mehta
- Department of Neuroradiology, West Virginia University, Nashville, TN, United States
- J. Levi Chazen
- Department of Radiology, Weill Cornell Medical College, New York, NY, United States
- Sally Hodder
- 0West Virginia Clinical and Translational Science Institute, West Virginia University, Morgantown, WV, United States
- Daniel Claassen
- Department of Neurology, Vanderbilt University, Nashville, TN, United States
- Michael Kaplitt
- 1Department of Neurological Surgery, Weill Cornell Medical College, New York, NY, United States
- Ali R. Rezai
- Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States
- Ali R. Rezai
- Department of Neurosurgery, West Virginia University, Nashville, TN, United States
- DOI
- https://doi.org/10.3389/fnhum.2020.593672
- Journal volume & issue
-
Vol. 14
Abstract
The blood–brain barrier (BBB) limits therapeutic delivery in Alzheimer’s disease (AD) and other neurological disorders. Animal models have demonstrated safe BBB opening and reduction in β-amyloid plaque with focused ultrasound (FUS). We recently demonstrated the feasibility, safety, and reversibility of FUS-induced BBB opening in the hippocampus and entorhinal cortex in six participants with early AD. We now report the effect of BBB opening with FUS treatment on β-amyloid plaque. Six participants underwent 18F-Florbetaben PET scan at baseline and 1 week after the completion of the third FUS treatment (60 days interval). PET analysis comparing the hippocampus and entorhinal cortex in the treated and untreated hemispheres revealed a decrease in the ratio of 18F-Florbetaben ligand binding. The standard uptake value ratios (SUVr) reduction ranged from 2.7% to 10% with an average of 5.05% (±2.76) suggesting a decrease in β-amyloid plaque.
Keywords
