Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis

Abstract

GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, rendering macrophages susceptible to bacterial infection.