A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase

• Mary Ortmayer,
• Florence J. Hardy,
• Matthew G. Quesne,
• Karl Fisher,
• Colin Levy,
• Derren J. Heyes,
• C. Richard A. Catlow,
• Sam P. de Visser,
• Stephen E. J. Rigby,
• Sam Hay,
• Anthony P. Green

Affiliations

Mary Ortmayer

Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

Florence J. Hardy

Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

Matthew G. Quesne

Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Oxford, Didcot, Oxon, United Kingdom

Karl Fisher

Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

Colin Levy

Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

Derren J. Heyes

Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

C. Richard A. Catlow

Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Oxford, Didcot, Oxon, United Kingdom

Sam P. de Visser

Department of Chemical Engineering and Analytical Science & Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

Stephen E. J. Rigby

Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

Sam Hay

Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

Anthony P. Green

Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom