Experience of Using Bedaquiline in a Young Child with Drug Resistant Tuberculosis and Concurrent Primary Immunodeficiency

Abstract

The article describes a clinical case of the treatment of a young child with a complicated course of tuberculosis with multiple localizations and concurrent primary immunodeficiency. The new anti-tuberculosis drug of bedaquiline was successfully used in the treatment regimen. The child received bedaquiline for 6 months without any adverse events, after 2 months no acid-fast mycobacteria were detected, there were pronounced positive radiological changes which remained until the end of treatment. This clinical case provides evidence that bedaquiline can be used safely and effectively in MDR TB chemotherapy regimens in children under 5 years of age.

Keywords

• дети
• химиотерапия туберкулеза
• вич-инфекция
• множественная лекарственная устойчивость
• бедаквилин