Nature Communications (Jul 2017)

Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair

  • Hiroyuki Niida,
  • Ryoichi Matsunuma,
  • Ryo Horiguchi,
  • Chiharu Uchida,
  • Yuka Nakazawa,
  • Akira Motegi,
  • Koji Nishimoto,
  • Satoshi Sakai,
  • Tatsuya Ohhata,
  • Kyoko Kitagawa,
  • Shinichi Moriwaki,
  • Hideo Nishitani,
  • Ayako Ui,
  • Tomoo Ogi,
  • Masatoshi Kitagawa

DOI
https://doi.org/10.1038/ncomms16102
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 18

Abstract

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Repair of cyclobutane pyrimidine dimers requires access to DNA by the nucleotide excision repair machinery. Here the authors show that HBO1 facilitates accumulation of SNF2H and ACF1 to make chromatin more accessible after ultraviolet damage.