Nature Communications (Oct 2022)
The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors
- Sujun Chen,
- Jessica Petricca,
- Wenbin Ye,
- Jiansheng Guan,
- Yong Zeng,
- Nicholas Cheng,
- Linsey Gong,
- Shu Yi Shen,
- Junjie T. Hua,
- Megan Crumbaker,
- Michael Fraser,
- Stanley Liu,
- Scott V. Bratman,
- Theodorus van der Kwast,
- Trevor Pugh,
- Anthony M. Joshua,
- Daniel D. De Carvalho,
- Kim N. Chi,
- Philip Awadalla,
- Guoli Ji,
- Felix Feng,
- Alexander W. Wyatt,
- Housheng Hansen He
Affiliations
- Sujun Chen
- Princess Margaret Cancer Center, University Health Network
- Jessica Petricca
- Princess Margaret Cancer Center, University Health Network
- Wenbin Ye
- Princess Margaret Cancer Center, University Health Network
- Jiansheng Guan
- Princess Margaret Cancer Center, University Health Network
- Yong Zeng
- Princess Margaret Cancer Center, University Health Network
- Nicholas Cheng
- Department of Medical Biophysics, University of Toronto
- Linsey Gong
- Princess Margaret Cancer Center, University Health Network
- Shu Yi Shen
- Princess Margaret Cancer Center, University Health Network
- Junjie T. Hua
- Department of Radiation Oncology, University of California
- Megan Crumbaker
- Department of Medical Oncology, Kinghorn Cancer Centre, St Vincent’s Hospital
- Michael Fraser
- Princess Margaret Cancer Center, University Health Network
- Stanley Liu
- Department of Medical Biophysics, University of Toronto
- Scott V. Bratman
- Princess Margaret Cancer Center, University Health Network
- Theodorus van der Kwast
- Department of Medical Biophysics, University of Toronto
- Trevor Pugh
- Princess Margaret Cancer Center, University Health Network
- Anthony M. Joshua
- Department of Pharmacology & Toxicology, University of Toronto
- Daniel D. De Carvalho
- Princess Margaret Cancer Center, University Health Network
- Kim N. Chi
- British Columbia Cancer Agency, Vancouver Centre
- Philip Awadalla
- Ontario Institute for Cancer Research
- Guoli Ji
- Department of Automation, Xiamen University
- Felix Feng
- Department of Radiation Oncology, University of California
- Alexander W. Wyatt
- Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia
- Housheng Hansen He
- Princess Margaret Cancer Center, University Health Network
- DOI
- https://doi.org/10.1038/s41467-022-34012-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Metastatic prostate cancer can be difficult to biopsy and characterise. Here, the authors use cell-free DNA methylation analysis to illustrate changes in hypermethylation in metastatic disease.
