CCT complex restricts neuropathogenic protein aggregation via autophagy

Mariana Pavel; Sara Imarisio; Fiona M. Menzies; Maria Jimenez-Sanchez; Farah H. Siddiqi; Xiaoting Wu; Maurizio Renna; Cahir J. O’Kane; Damian C. Crowther; David C. Rubinsztein

doi:10.1038/ncomms13821

Nature Communications (Dec 2016)

CCT complex restricts neuropathogenic protein aggregation via autophagy

Mariana Pavel,
Sara Imarisio,
Fiona M. Menzies,
Maria Jimenez-Sanchez,
Farah H. Siddiqi,
Xiaoting Wu,
Maurizio Renna,
Cahir J. O’Kane,
Damian C. Crowther,
David C. Rubinsztein

Affiliations

Mariana Pavel: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital
Sara Imarisio: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital
Fiona M. Menzies: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital
Maria Jimenez-Sanchez: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital
Farah H. Siddiqi: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital
Xiaoting Wu: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital
Maurizio Renna: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital
Cahir J. O’Kane: Department of Genetics, University of Cambridge
Damian C. Crowther: Department of Genetics, University of Cambridge
David C. Rubinsztein: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital

DOI: https://doi.org/10.1038/ncomms13821
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 18

Abstract

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The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavelet al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 depletion is primarily a consequence of impaired autophagy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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