Mediators of Inflammation (Jan 2010)

Levels of Salivary IFN-gamma, TNF-Alfa, and TNF Receptor-2 As Prognostic Markers in (Erosive) Oral Lichen Planus

  • Noha A. Ghallab,
  • Naglaa El-Wakeel,
  • Olfat G. Shaker

DOI
https://doi.org/10.1155/2010/847632
Journal volume & issue
Vol. 2010

Abstract

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To explore the feasibility of detecting salivary levels of IFN-γ, TNF-α, and sTNFR-2 from erosive oral lichen planus (ELP) patients for clinical application, 20 ELP patients were enrolled in the study as were 20 age-sex-matched controls. From all subjects, saliva level of the tested biomarkers was determined by ELISA. Salivary profiles were assessed in ELP patients by ELISA after being treated with prednisone. A significantly higher level of IFN-γ (P≤.01), TNF-α (P≤.0001), and sTNFR-2 (P≤.01) was detected in ELP patients before treatment than in controls. Following treatment, the salivary levels of IFN-γ (P≤.01), TNF-α (P≤.05), and sTNFR-2 (P≤.01) decreased significantly when compared to their pretreatment levels. This study demonstrated that salivary IFN-γ, TNF-α, and sTNFR-2 can be detectable in ELP patients and decreased significantly after treatment with prednisone, which may reveal the possibility of using these disease-related biomarkers in diagnosis and monitoring.