Nature Communications (Aug 2020)

GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

  • Wei Zhou,
  • Ben Brumpton,
  • Omer Kabil,
  • Julius Gudmundsson,
  • Gudmar Thorleifsson,
  • Josh Weinstock,
  • Matthew Zawistowski,
  • Jonas B. Nielsen,
  • Layal Chaker,
  • Marco Medici,
  • Alexander Teumer,
  • Silvia Naitza,
  • Serena Sanna,
  • Ulla T. Schultheiss,
  • Anne Cappola,
  • Juha Karjalainen,
  • Mitja Kurki,
  • Morgan Oneka,
  • Peter Taylor,
  • Lars G. Fritsche,
  • Sarah E. Graham,
  • Brooke N. Wolford,
  • William Overton,
  • Humaira Rasheed,
  • Eirin B. Haug,
  • Maiken E. Gabrielsen,
  • Anne Heidi Skogholt,
  • Ida Surakka,
  • George Davey Smith,
  • Anita Pandit,
  • Tanmoy Roychowdhury,
  • Whitney E. Hornsby,
  • Jon G. Jonasson,
  • Leigha Senter,
  • Sandya Liyanarachchi,
  • Matthew D. Ringel,
  • Li Xu,
  • Lambertus A. Kiemeney,
  • Huiling He,
  • Romana T. Netea-Maier,
  • Jose I. Mayordomo,
  • Theo S. Plantinga,
  • Jon Hrafnkelsson,
  • Hannes Hjartarson,
  • Erich M. Sturgis,
  • Aarno Palotie,
  • Mark Daly,
  • Cintia E. Citterio,
  • Peter Arvan,
  • Chad M. Brummett,
  • Michael Boehnke,
  • Albert de la Chapelle,
  • Kari Stefansson,
  • Kristian Hveem,
  • Cristen J. Willer,
  • Bjørn Olav Åsvold

DOI
https://doi.org/10.1038/s41467-020-17718-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

Read online

Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. Here, the authors conduct a GWAS and suggest protective effect of higher TSH on risk of thyroid cancer and goitre.