Nature Communications (Aug 2020)
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
- Wei Zhou,
- Ben Brumpton,
- Omer Kabil,
- Julius Gudmundsson,
- Gudmar Thorleifsson,
- Josh Weinstock,
- Matthew Zawistowski,
- Jonas B. Nielsen,
- Layal Chaker,
- Marco Medici,
- Alexander Teumer,
- Silvia Naitza,
- Serena Sanna,
- Ulla T. Schultheiss,
- Anne Cappola,
- Juha Karjalainen,
- Mitja Kurki,
- Morgan Oneka,
- Peter Taylor,
- Lars G. Fritsche,
- Sarah E. Graham,
- Brooke N. Wolford,
- William Overton,
- Humaira Rasheed,
- Eirin B. Haug,
- Maiken E. Gabrielsen,
- Anne Heidi Skogholt,
- Ida Surakka,
- George Davey Smith,
- Anita Pandit,
- Tanmoy Roychowdhury,
- Whitney E. Hornsby,
- Jon G. Jonasson,
- Leigha Senter,
- Sandya Liyanarachchi,
- Matthew D. Ringel,
- Li Xu,
- Lambertus A. Kiemeney,
- Huiling He,
- Romana T. Netea-Maier,
- Jose I. Mayordomo,
- Theo S. Plantinga,
- Jon Hrafnkelsson,
- Hannes Hjartarson,
- Erich M. Sturgis,
- Aarno Palotie,
- Mark Daly,
- Cintia E. Citterio,
- Peter Arvan,
- Chad M. Brummett,
- Michael Boehnke,
- Albert de la Chapelle,
- Kari Stefansson,
- Kristian Hveem,
- Cristen J. Willer,
- Bjørn Olav Åsvold
Affiliations
- Wei Zhou
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Ben Brumpton
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Omer Kabil
- Department of Biological Chemistry, University of Michigan Medical School
- Julius Gudmundsson
- deCODE genetics/AMGEN
- Gudmar Thorleifsson
- deCODE genetics/AMGEN
- Josh Weinstock
- Center for Statistical Genetics and Department of Biostatistics, University of Michigan School of Public Health
- Matthew Zawistowski
- Center for Statistical Genetics and Department of Biostatistics, University of Michigan School of Public Health
- Jonas B. Nielsen
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Layal Chaker
- Erasmus MC Academic Center for Thyroid Diseases
- Marco Medici
- Erasmus MC Academic Center for Thyroid Diseases
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Silvia Naitza
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato
- Serena Sanna
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato
- Ulla T. Schultheiss
- Faculty of Medicine and Medical Center, Institute of Genetic Epidemiology, University of Freiburg
- Anne Cappola
- Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine
- Juha Karjalainen
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Mitja Kurki
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Morgan Oneka
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Peter Taylor
- Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine
- Lars G. Fritsche
- Center for Statistical Genetics and Department of Biostatistics, University of Michigan School of Public Health
- Sarah E. Graham
- Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School
- Brooke N. Wolford
- Department of Computational Medicine and Bioinformatics, University of Michigan
- William Overton
- Center for Statistical Genetics and Department of Biostatistics, University of Michigan School of Public Health
- Humaira Rasheed
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Eirin B. Haug
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Maiken E. Gabrielsen
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Anne Heidi Skogholt
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Ida Surakka
- Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School
- George Davey Smith
- Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol
- Anita Pandit
- Center for Statistical Genetics and Department of Biostatistics, University of Michigan School of Public Health
- Tanmoy Roychowdhury
- Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School
- Whitney E. Hornsby
- Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School
- Jon G. Jonasson
- Landspitali-University Hospital
- Leigha Senter
- Division of Human Genetics, Ohio State University Comprehensive Cancer Center
- Sandya Liyanarachchi
- Department of Cancer Biology and Genetics, Ohio State University Comprehensive Cancer Center
- Matthew D. Ringel
- Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University
- Li Xu
- Department of Head and Neck Surgery, and Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Lambertus A. Kiemeney
- Radboud University Medical Centre, Radboud Institute for Health Sciences
- Huiling He
- Department of Cancer Biology and Genetics, Ohio State University Comprehensive Cancer Center
- Romana T. Netea-Maier
- Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences
- Jose I. Mayordomo
- University of Colorado Hospital
- Theo S. Plantinga
- Department of Pathology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences
- Jon Hrafnkelsson
- Landspitali-University Hospital
- Hannes Hjartarson
- Landspitali-University Hospital
- Erich M. Sturgis
- Department of Head and Neck Surgery, and Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Aarno Palotie
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Mark Daly
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Cintia E. Citterio
- Division of Metabolism Endocrinology and Diabetes, University of Michigan Medical School
- Peter Arvan
- Division of Metabolism Endocrinology and Diabetes, University of Michigan Medical School
- Chad M. Brummett
- Division of Pain Medicine, Department of Anesthesiology, University of Michigan Medical School
- Michael Boehnke
- Center for Statistical Genetics and Department of Biostatistics, University of Michigan School of Public Health
- Albert de la Chapelle
- Department of Cancer Biology and Genetics, Ohio State University Comprehensive Cancer Center
- Kari Stefansson
- deCODE genetics/AMGEN
- Kristian Hveem
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Cristen J. Willer
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Bjørn Olav Åsvold
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-020-17718-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. Here, the authors conduct a GWAS and suggest protective effect of higher TSH on risk of thyroid cancer and goitre.
