International Journal of Nanomedicine (2020-09-01)

The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics

  • Li H,
  • Xia P,
  • Pan S,
  • Qi Z,
  • Fu C,
  • Yu Z,
  • Kong W,
  • Chang Y,
  • Wang K,
  • Wu D,
  • Yang X

Journal volume & issue
Vol. Volume 15
pp. 7199 – 7214


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Hongru Li, Peng Xia, Su Pan, Zhiping Qi, Chuan Fu, Ziyuan Yu, Weijian Kong, Yuxin Chang, Kai Wang, Dankai Wu, Xiaoyu Yang Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of ChinaCorrespondence: Dankai Wu; Xiaoyu YangDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, TX 130041, People’s Republic of ChinaEmail [email protected]; [email protected]: The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO2-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that CeO2-NPs, a nanozyme based on inorganic nanoparticles, can achieve the anti-inflammatory effect, cancer resistance, and angiogenesis. Also, they can well complement other materials in tissue engineering (TE). Pertinent to the properties of CeO2-NPs and the pragmatic biosynthesis methods, this review will emphasize the recent application of CeO2-NPs to orthopedic biomedicine, in particular, the bone tissue engineering (BTE). The presentation, assessment, and outlook of the orthopedic potential and shortcomings of CeO2-NPs in this review expect to provide reference values for the future research and development of therapeutic agents based on CeO2-NPs.Keywords: CeO2-NPs, green synthesis, ROS, bone tissue engineering, coating, orthopedic implants