Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell

Ao Shen; Madeline Nieves-Cintron; Yawen Deng; Qian Shi; Dhrubajyoti Chowdhury; Jinyi Qi; Johannes W. Hell; Manuel F. Navedo; Yang K. Xiang

doi:10.1038/s41467-018-03459-7

Nature Communications (Mar 2018)

Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell

Ao Shen,
Madeline Nieves-Cintron,
Yawen Deng,
Qian Shi,
Dhrubajyoti Chowdhury,
Jinyi Qi,
Johannes W. Hell,
Manuel F. Navedo,
Yang K. Xiang

Affiliations

Ao Shen: Department of Pharmacology, University of California Davis
Madeline Nieves-Cintron: Department of Pharmacology, University of California Davis
Yawen Deng: Department of Pharmacology, University of California Davis
Qian Shi: Department of Pharmacology, University of California Davis
Dhrubajyoti Chowdhury: Department of Pharmacology, University of California Davis
Jinyi Qi: Department of Biomedical Engineering, University of California Davis
Johannes W. Hell: Department of Pharmacology, University of California Davis
Manuel F. Navedo: Department of Pharmacology, University of California Davis
Yang K. Xiang: Department of Pharmacology, University of California Davis

DOI: https://doi.org/10.1038/s41467-018-03459-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

β2-adrenergic receptor (β2AR) can be phosphorylated by G protein receptor kinases and second messenger-dependent kinases. Here, the authors demonstrate that these phosphorylation events are specific to functionally distinct and spatially segregated subpopulations of β2AR that co-exist in a single cell.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal