Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

Zhou Zhong; Jiying Ning; Emerson A. Boggs; Sooin Jang; Callen Wallace; Cheryl Telmer; Marcel P. Bruchez; Jinwoo Ahn; Alan N. Engelman; Peijun Zhang; Simon C. Watkins; Zandrea Ambrose

doi:10.1128/mBio.03142-20

mBio (Apr 2021)

Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

Zhou Zhong,
Jiying Ning,
Emerson A. Boggs,
Sooin Jang,
Callen Wallace,
Cheryl Telmer,
Marcel P. Bruchez,
Jinwoo Ahn,
Alan N. Engelman,
Peijun Zhang,
Simon C. Watkins,
Zandrea Ambrose

Affiliations

Zhou Zhong: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Jiying Ning: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Emerson A. Boggs: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Sooin Jang: Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Callen Wallace: Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Cheryl Telmer: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
Marcel P. Bruchez: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
Jinwoo Ahn: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Alan N. Engelman: Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Peijun Zhang: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Simon C. Watkins: Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Zandrea Ambrose: ORCiD; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

DOI: https://doi.org/10.1128/mBio.03142-20
Journal volume & issue: Vol. 12, no. 2

Abstract

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HIV is the causative agent of AIDS, which has no cure. The protein shell that encases the viral genome, the capsid, is critical for HIV replication in cells at multiple steps.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal