From mouse genetics to targeting the Rag GTPase pathway

Abstract

The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease. Recent mouse genetic studies have provided pathophysiological insight and pointed to potential indications for inhibitors of the Rag GTPase pathway.

Keywords

• mtor
• rag gtpases; nutrients
• b cells
• lymphoma
• small molecules
• mice