Frontiers in Immunology (Jun 2021)

The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

  • Noymar Luque-Campos,
  • Noymar Luque-Campos,
  • Noymar Luque-Campos,
  • Felipe A. Bustamante-Barrientos,
  • Felipe A. Bustamante-Barrientos,
  • Carolina Pradenas,
  • Carolina Pradenas,
  • Carolina Pradenas,
  • Cynthia García,
  • Cynthia García,
  • Cynthia García,
  • María Jesús Araya,
  • María Jesús Araya,
  • María Jesús Araya,
  • Candice Bohaud,
  • Rafael Contreras-López,
  • Roberto Elizondo-Vega,
  • Farida Djouad,
  • Patricia Luz-Crawford,
  • Patricia Luz-Crawford,
  • Ana María Vega-Letter,
  • Ana María Vega-Letter,
  • Ana María Vega-Letter

DOI
https://doi.org/10.3389/fimmu.2021.624746
Journal volume & issue
Vol. 12

Abstract

Read online

Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.

Keywords