Correlation Between Glycemic Variability and Diabetic Complications: A Narrative Review

Abstract

Lining Huang,1 Ying Pan,1 Kaixin Zhou,2 Hongying Liu,3 Shao Zhong1 1Department of Endocrinology, Gusu School, Nanjing Medical University, The First People’s Hospital of Kunshan, Kunshan, 215300, People’s Republic of China; 2Guangzhou Laboratory, Guangzhou, 510005, People’s Republic of China; 3Hangzhou Kang Ming Information Technology Co., Ltd, Hangzhou, 310000, People’s Republic of ChinaCorrespondence: Shao Zhong, Department of Endocrinology, Gusu School, Nanjing Medical University, The First People’s Hospital of Kunshan, Kunshan, 215300, People’s Republic of China, Tel [phone], Email [email protected] Hongying Liu, Hangzhou Kang Ming Information Technology Co., Ltd, Hangzhou, 310000, People’s Republic of China, Email [email protected]: Diabetes mellitus is a metabolic disorder with a complex etiology in which glycemic dynamics are disturbed and the body is unable to maintain the process of glucose homeostasis through the pancreas. Persistent symptoms of high blood glucose or low blood glucose may lead to diabetic complications, such as neuropathy, nephropathy, retinopathy, and cardiovascular diseases. Glycemic variability which can represent the presence of excessive glycemic excursions is an indicator for evaluating glucose homoeostasis. Limiting glycemic variability has gradually become an emerging therapeutic target in improve diabetes metabolism and prevent associated complications. This article reviews the progress of research on the various quantifiable parameters of glycemic variability and their relationships with vascular lesions and mechanisms.Keywords: diabetes mellitus, glycemic variability, glycemic variability parameters, vascular lesions of diabetes mellitus

Keywords

• diabetes mellitus
• glycemic variability
• glycemic variability parameters
• vascular lesions of diabetes mellitus.