Frontiers in Public Health (Apr 2023)

Progress in biological age research

  • Zhe Li,
  • Zhe Li,
  • Weiguang Zhang,
  • Yuting Duan,
  • Yuting Duan,
  • Yue Niu,
  • Yizhi Chen,
  • Yizhi Chen,
  • Xiaomin Liu,
  • Zheyi Dong,
  • Ying Zheng,
  • Xizhao Chen,
  • Zhe Feng,
  • Yong Wang,
  • Delong Zhao,
  • Xuefeng Sun,
  • Guangyan Cai,
  • Hongwei Jiang,
  • Xiangmei Chen

DOI
https://doi.org/10.3389/fpubh.2023.1074274
Journal volume & issue
Vol. 11

Abstract

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Biological age (BA) is a common model to evaluate the function of aging individuals as it may provide a more accurate measure of the extent of human aging than chronological age (CA). Biological age is influenced by the used biomarkers and standards in selected aging biomarkers and the statistical method to construct BA. Traditional used BA estimation approaches include multiple linear regression (MLR), principal component analysis (PCA), Klemera and Doubal’s method (KDM), and, in recent years, deep learning methods. This review summarizes the markers for each organ/system used to construct biological age and published literature using methods in BA research. Future research needs to explore the new aging markers and the standard in select markers and new methods in building BA models.

Keywords