European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction

Emmanuel Weyne, MD, PhD; Marcus M. Ilg, PhD; Onur Omer Cakir, MD; Asif Muneer, MD; Delphine Behr Roussel, PhD; Maarten Albersen, MD, PhD; Javier Angulo, PhD; Giovanni Corona, MD, PhD; Carlo Bettocchi, MD; Yacov Reisman, MD, PhD; Fabio Castiglione, MD, PhD

Sexual Medicine (Sep 2020)

European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction

Emmanuel Weyne, MD, PhD,
Marcus M. Ilg, PhD,
Onur Omer Cakir, MD,
Asif Muneer, MD,
Delphine Behr Roussel, PhD,
Maarten Albersen, MD, PhD,
Javier Angulo, PhD,
Giovanni Corona, MD, PhD,
Carlo Bettocchi, MD,
Yacov Reisman, MD, PhD,
Fabio Castiglione, MD, PhD

Affiliations

Emmanuel Weyne, MD, PhD: Laboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium
Marcus M. Ilg, PhD: Faculty of Health, Education, Medicine and Social Care, Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, UK
Onur Omer Cakir, MD: Department of Urology, University College London Hospitals NHS Trust, London, UK; Division of Surgery and Interventional Science, UCL, London, UK
Asif Muneer, MD: Department of Urology, University College London Hospitals NHS Trust, London, UK; Division of Surgery and Interventional Science, UCL, London, UK; NIHR Biomedical Research Centre University College London Hospitals, London, UK
Delphine Behr Roussel, PhD: Pelvipharm, Montigny-le-Bretonneux, France UMR1179, Université Versailles Saint Quentin en Yvelines, Montigny-le-Bretonneux, France
Maarten Albersen, MD, PhD: Laboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium
Javier Angulo, PhD: Servicio de Histología-Investigación, Unidad de Investigación Traslacional en Cardiología (UFV-IRYCIS), Hospital Universitario Ramón y Cajal, Madrid, Spain
Giovanni Corona, MD, PhD: Endocrinology Unit, Medical Department, Azienda USL, Maggiore-Bellaria Hospital, Bologna, Italy
Carlo Bettocchi, MD: Division of Urology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
Yacov Reisman, MD, PhD: Flare-Health, Amstelveen, The Netherlands
Fabio Castiglione, MD, PhD: Department of Urology, University College London Hospitals NHS Trust, London, UK; Division of Surgery and Interventional Science, UCL, London, UK; Unit of Urology, Division of Experimental Oncology, Urological Research Institute (URI), IRCCS Ospedale San Raffaele, Milan, Italy; Departement of Urology, Vita-Salute San Raffaele University, Milan, Italy; Corresponding Author: Fabio Castiglione, MD, PhD, Departement of Urology, University College London Hospital, 16-18 Westmoreland St, Marylebone, London W1G 8PH. Tel: +447460050365

Journal volume & issue: Vol. 8, no. 3
pp. 327 – 337

Abstract

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Introduction: Rodent animal models are currently the most used in vivo model in translational studies looking into the pathophysiology of erectile dysfunction after nerve-sparing radical prostatectomy. Aim: This European Society for Sexual Medicine (ESSM) statement aims to guide scientists toward utilization of the rodent model in an appropriate, timely, and proficient fashion. Methods: MEDLINE and EMBASE databases were searched for basic science studies, using a rodent animal model, looking into the consequence of pelvic nerve injury on erectile function. Main outcome measures: The authors present a consensus on how to best perform experiments with this rodent model, the details of the technique, and highlight possible pitfalls. Results: Owing to the specific issue—basic science—Oxford 2011 Levels of Evidence criteria cannot be applied. However, ESSM statements on this topic will be provided in which we summarize the ESSM position on various aspects of the model such as the use of the Animal Research Reporting In Vivo Experiments guideline and the of common range parameter for nerve stimulation. We also highlighted the translational limits of the model. Conclusion: The following statements were formulated as a suggestive guidance for scientists using the cavernous nerve injury model. With this, we hope to standardize and further improve the quality of research in this field. It must be noted that this model has its limitations.Weyne E, Ilg MM, Cakir OO, et al. European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction. Sex Med 2020;8:327–337.

Published in Sexual Medicine

ISSN: 2050-1161 (Online)
Publisher: Oxford University Press
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://academic.oup.com/smoa

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