Nature Communications (Dec 2021)
CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation
- Itziar Otano,
- Arantza Azpilikueta,
- Javier Glez-Vaz,
- Maite Alvarez,
- José Medina-Echeverz,
- Ivan Cortés-Domínguez,
- Carlos Ortiz-de-Solorzano,
- Peter Ellmark,
- Sara Fritzell,
- Gabriela Hernandez-Hoyos,
- Michelle Hase Nelson,
- María Carmen Ochoa,
- Elixabet Bolaños,
- Doina Cuculescu,
- Patricia Jaúregui,
- Sandra Sanchez-Gregorio,
- Iñaki Etxeberria,
- María E. Rodriguez-Ruiz,
- Miguel F. Sanmamed,
- Álvaro Teijeira,
- Pedro Berraondo,
- Ignacio Melero
Affiliations
- Itziar Otano
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Arantza Azpilikueta
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Javier Glez-Vaz
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Maite Alvarez
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- José Medina-Echeverz
- Bavarian Nordic GmbH
- Ivan Cortés-Domínguez
- Navarra Institute for Health Research (IDISNA)
- Carlos Ortiz-de-Solorzano
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
- Peter Ellmark
- Alligator Bioscience
- Sara Fritzell
- Alligator Bioscience
- Gabriela Hernandez-Hoyos
- Aptevo Therapeutics
- Michelle Hase Nelson
- Aptevo Therapeutics
- María Carmen Ochoa
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Elixabet Bolaños
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
- Doina Cuculescu
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Patricia Jaúregui
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
- Sandra Sanchez-Gregorio
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Iñaki Etxeberria
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- María E. Rodriguez-Ruiz
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Miguel F. Sanmamed
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Álvaro Teijeira
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Pedro Berraondo
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- Ignacio Melero
- Program of Immunology and Immunotherapy, Cima Universidad de Navarra
- DOI
- https://doi.org/10.1038/s41467-021-27613-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Costimulation has been shown to be required for optimal activation of T cells and it could be delivered either in trans with respect to the source of CD3-TCR ligation or in cis on the same cell. Here the authors show that CD137 costimulation is more effective when delivered in cis to enhance T cell proliferation and activation.
