Lanthanide-Based Organic Salts: Synthesis, Characterization, and Cytotoxicity Studies
Andreia Forte,
Sandra Gago,
Celso Alves,
Joana Silva,
Joana Alves,
Rui Pedrosa,
César A. T. Laia,
Isabel M. Marrucho,
Luis C. Branco
Affiliations
Andreia Forte
Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal
Sandra Gago
Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal
Celso Alves
MARE—Marine and Environmental Sciences Centre/ARNET, ESTM, Politécnico de Leiria, Rua do Conhecimento, No. 4, 2520-614 Peniche, Portugal
Joana Silva
MARE—Marine and Environmental Sciences Centre/ARNET, ESTM, Politécnico de Leiria, Rua do Conhecimento, No. 4, 2520-614 Peniche, Portugal
Joana Alves
MARE—Marine and Environmental Sciences Centre/ARNET, ESTM, Politécnico de Leiria, Rua do Conhecimento, No. 4, 2520-614 Peniche, Portugal
Rui Pedrosa
MARE—Marine and Environmental Sciences Centre/ARNET, ESTM, Politécnico de Leiria, Rua do Conhecimento, No. 4, 2520-614 Peniche, Portugal
César A. T. Laia
Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal
Isabel M. Marrucho
ITQB NOVA—Instituto de Tecnologia Química e Biológica António Xavier, Avenida da República, Estação Agronómica Nacional, 2780-157 Oeiras, Portugal
Luis C. Branco
Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal
The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. The magnetic moments obtained for the Gd(III) salts were, as expected, smaller than those obtained for the Tb(III)-based compounds. The values for Gd(III) and Tb(III) magnetic salts are in the range of 6.55–7.30 MB and 8.22–9.34 MB, respectively. It is important to note a correlation between the magnetic moments obtained for lanthanides, and the structural features of the cation. The cytotoxicity of lanthanide-based salts was also evaluated using 3T3, 293T, Caco2, and HepG2 cells, and it was revealed that most of the prepared compounds are not toxic.
