Thermoanalytical studies of cimetidine and complexes with Mn(II) Co(II) and Ni(II)

Abstract

Cimetidine is an important hydrogen histamine receptor and can coordinate metal ions in blood plasma. The stability of cimetidine and its complexes with Mn(II), Co(II) and Ni(II) was evaluated by studies of thermogravimetry (TG) and differential thermal analysis (DTA). Cimetidine was thermally stable up to near 190 °C and above this temperature the thermal decomposition occurred in two stages. Complexes of [Mn(HCm)2]Cl2, [Co(Cm)2]Cl2 and [Ni(Cm)2]Cl2 showed a similar behavior. The pyrolytic decomposition occurred in two stages at temperatures above 250 oC. A residue for each complex was detected at the end of the decomposition process. This probably corresponds to the respective metal oxide.

Keywords

• Cimetidine
• Complex