Emerging Infectious Diseases (Apr 2020)

Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan

  • Chi-Jung Wu,
  • Wei-Lun Liu,
  • Chih-Cheng Lai,
  • Chien-Ming Chao,
  • Wen-Chien Ko,
  • Hsuan-Chen Wang,
  • Ching-Tzu Dai,
  • Ming-I Hsieh,
  • Pui-Ching Choi,
  • Jia-Ling Yang,
  • Yee-Chun Chen

DOI
https://doi.org/10.3201/eid2604.190840
Journal volume & issue
Vol. 26, no. 4
pp. 804 – 806

Abstract

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In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR34/L98H, TR34/L98H/S297T/F495I, and TR46/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.

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