Российский журнал гастроэнтерологии, гепатологии, колопроктологии (Dec 2015)
Prevalence of non-alcoholic fatty liver disease in out-patients of the Russian Federation: DIREG 2 study results
Abstract
Aim of investigation. Primary objective: to estimate the prevalence of NAFLD within the general practitioner’s and gastroenterologist’s patient flow.Materials and methods. The prospective disease registry was carried out as epidemiologic, observational, cross-sectional, multicenter investigation to assess NAFLD prevalence at outpatient practice in the Russian Federation. A total of 50145 patients meeting the inclusion/exclusion criteria in 16 Russian cities were enrolled this study registry. Overall 1031 qualified doctors (GPs/therapists/gastroenterologists/pediatricians), providing outpatient care for the population, were study investigators. The epidemiological data were obtained andrecorded during two routine patient admissions to investigating centers. Acad. of the Russian Academy of science V.T. Ivashkin and Prof. O.M. Drapkina were national coordinators of the study.Results. The rate NAFLD cases within primary or secondary patients, who admitted the healthcare institutions for any reason, including those with suspected NAFLD was 37,3%. The main trend for non-cirrhotic non-alcoholic fatty liver disease (NANCFLD) prevalence was the progressive increase along with age from 2,90% in 12–17 y.o. patients to 42,96% in 60–69 y.o. patients. The highest prevalence of non-alcoholic steatosis (NAS) was 34,26% in patients aged 70–80. Non-alcoholic steatohepatitis (NASH) was most frequent in patients aged 50–59 (10,95%).Conclusion. Prevalence of NAFLD in outpatients in Russia increased from the year 2007 to 2015 and reached 37,3%. The high prevalence of NANCFLD was revealed in primary or secondary patients admitted healthcare institutions for any reason including those with suspected NAFLD (patients with obesity, type 2 diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, hypercholesterolemia).
