A European Multicentric Investigation of Atypical Melanocytic Skin Lesions of Palms and Soles: The <i>iDScore-PalmoPlantar</i> Database
Linda Tognetti,
Alessandra Cartocci,
Aimilios Lallas,
Elvira Moscarella,
Ignazio Stanganelli,
Gianluca Nazzaro,
John Paoli,
Maria Concetta Fargnoli,
Paolo Broganelli,
Harald Kittler,
Jean-Luc Perrot,
Gennaro Cataldo,
Gabriele Cevenini,
Sofia Lo Conte,
Leonardelli Simone,
Elisa Cinotti,
Pietro Rubegni
Affiliations
Linda Tognetti
Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, 53100 Siena, Italy
Alessandra Cartocci
Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, 53100 Siena, Italy
Aimilios Lallas
First Department of Dermatology, Aristotle University, 54124 Thessaloniki, Greece
Elvira Moscarella
Dermatology Unit, University of Campania Luigi Vanvitelli, 81100 Naples, Italy
Ignazio Stanganelli
Skin Cancer Unit, Scientific Institute of Romagna for the Study of Cancer, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Tumori della Romagna (IRST), 47014 Meldola, Italy
Gianluca Nazzaro
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
John Paoli
Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41390 Gothenburg, Sweden
Maria Concetta Fargnoli
Dermatology Unit, University of L’Aquila, 67100 L’Aquila, Italy
Paolo Broganelli
Dermatology Unit, University Hospital of Torino, 4020 Torino, Italy
Harald Kittler
Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria
Jean-Luc Perrot
Dermatology Unit, University Hospital of St-Etienne, 42270 Saint Etienne, France
Gennaro Cataldo
Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy
Gabriele Cevenini
Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy
Sofia Lo Conte
Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, 53100 Siena, Italy
Leonardelli Simone
Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, 53100 Siena, Italy
Elisa Cinotti
Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, 53100 Siena, Italy
Pietro Rubegni
Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, 53100 Siena, Italy
Background: The differential diagnosis of atypical melanocytic palmoplantar skin lesions (aMPLs) represents a diagnostic challenge, including atypical nevi (AN) and early melanomas (MMs) that display overlapping clinical and dermoscopic features. We aimed to set up a multicentric dataset of aMPL dermoscopic cases paired with multiple anamnestic risk factors and demographic and morphologic data. Methods: Each aMPL case was paired with a dermoscopic and clinical picture and a series of lesion-related data (maximum diameter value; location on the palm/sole in 17 areas; histologic diagnosis; and patient-related data (age, sex, family history of melanoma/sunburns, phototype, pheomelanin, eye/hair color, multiple/dysplastic body nevi, and traumatism on palms/soles). Results: A total of 542 aMPL cases—113 MM and 429 AN—were collected from 195 males and 347 females. No sex prevalence was found for melanomas, while women were found to have relatively more nevi. Melanomas were prevalent on the heel, plantar arch, and fingers in patients aged 65.3 on average, with an average diameter of 17 mm. Atypical nevi were prevalent on the plantar arch and palmar area of patients aged 41.33 on average, with an average diameter of 7 mm. Conclusions: Keeping in mind the risk profile of an aMPL patient can help obtain a timely differentiation between malignant/benign cases, thus avoiding delayed and inappropriate excision, respectively, with the latter often causing discomfort/dysfunctional scarring, especially at acral sites.
