Two Cases of Congenital Hypothyroidism in Two Sets of Twins with Fetal Goiter

Abstract

BACKGROUND AND OBJECTIVE: Congenital hypothyroidism is a neonatal disorder that late diagnosis and treatment of it can be resulted to mental retardation and irreversible brain damage. Neonatal goiter is a rare condition that can be associated with hypothyroidism or hyperthyroidism. The aim of this report is early diagnosis and treatment. CASE: In this article we report two female twins that had goiter and prenatal diagnosis by ultrasonography had been documented for them. At third days of life patients with diagnosis of congenital hypothyroidism treated with Levothyroxin. Now they are 10 months old and developmentally normal. Size of goiter has been reduced and thyroid function tests are acceptable.CONCLUSION: Results of this report revealed that in conditions that prenatal management of fetal goiter is not available brain damage in patients can be prevented by early etiologic diagnosis of neonatal goiter and early treatment of dyshormonogenesis.

Keywords

• fetal goiter
• dyshormonogenesis
• neonatal goiter
• neonatal hypothyroidism