PLoS ONE (Jan 2018)

Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR.

  • Johannes Patzelt,
  • Miriam Ulrich,
  • Annika Becker,
  • Karin A L Müller,
  • Rezo Jorbenadze,
  • Michal Droppa,
  • Wenzhong Zhang,
  • Sarah Mandel,
  • Lisa Habel,
  • Henning Lausberg,
  • Janine Pöss,
  • Tobias Geisler,
  • Oliver Borst,
  • Peter Rosenberger,
  • Christian Schlensak,
  • Meinrad Gawaz,
  • Jürgen Schreieck,
  • Peter Seizer,
  • Harald F Langer

DOI
https://doi.org/10.1371/journal.pone.0205930
Journal volume & issue
Vol. 13, no. 10
p. e0205930

Abstract

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BACKGROUND:Patients after transcatheter aortic valve replacement (TAVR) and persistent severe mitral regurgitation (MR) are increasingly treated with percutaneous edge-to-edge mitral valve repair (PMVR). The impact of a former TAVR on PMVR procedures is not clear. METHODS AND RESULTS:We retrospectively analyzed 332 patients undergoing PMVR using the MitraClip system with respect to procedural and clinical outcome. 21 of these 332 patients underwent TAVR before PMVR. Intra-procedural transthoracic (TTE) and transesophageal echocardiograms (TEE) immediately before and after clip implantation as well as invasive hemodynamic measurements were evaluated. At baseline, we found a significantly smaller mitral valve anterior-posterior diameter in the TAVR cohort (p < 0.001). A reduction of MR by at least three grades was achieved in a smaller fraction in the TAVR cohort as compared to the cohort with a native aortic valve (p = 0.02). Accordingly, we observed a smaller post-procedural cardiac output in the TAVR cohort (p = 0.02). CONCLUSION:PMVR in patients who had a TAVR before, is associated with altered MR anatomy before and a reduced improvement of MR after the procedure. Future larger and prospective studies will have to determine, whether a previous TAVR influences long-term clinical outcome of patients undergoing PMVR.