Efficient synthesis of dipeptide analogues of α-fluorinated β-aminophosphonates

Abstract

Herein, we present an efficient synthesis of dipeptide analogues of α-fluorinated β-aminophosphonates. Each step of the synthesis was optimized to provide excellent yields. Moreover, the absolute configuration of the obtained compounds was determined by X-ray analysis, which proved the stereochemistry that was proposed based on NMR studies.

Keywords

• dipeptide analogues
• fluorinated aminophosphonates
• fluorine
• nucleophilic fluorination
• phosphorus